Sodium borohydride → HCID 18334264、化合物

HRID 2269496ノート

反応式

HRID 2269496 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([N+:27]([O-])=O)[CH:22]=2)[NH:9][CH:10]([C:12]2[CH:17]=[C:16]([F:18])[C:15]([F:19])=[C:14]([F:20])[CH:13]=2)[CH3:11])=[CH:4][CH:3]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:9][CH:10]([C:12]2[CH:13]=[C:14]([F:20])[C:15]([F:19])=[C:16]([F:18])[CH:17]=2)[CH3:11])[C:21]2[CH:22]=[C:23]([NH2:27])[CH:24]=[CH:25][CH:26]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 18334146HCID 18334146、化合物

生成物 1

HCID 18334264HCID 18334264、化合物

試薬・触媒・溶媒 1

HCID 11791229Dichloronickel;hexahydrate触媒

実験手順

Following a similar reaction, separation and purification procedure to that described in Example (59b), 2.71 g of N-[(4-chlorophenyl)-(3-nitrophenyl)methyl]-N-[1-(3,4,5-trifluorophenyl)ethyl]amine [prepared as described in step (a) above], 3.06 g of nickel chloride hexahydrate and 973 mg of sodium borohydride were reacted, to obtain 946 mg of isomer A and 691 mg of isomer B of the title compound as a colorless oil and white solid, respectively.

後処理

  1. customa similar reaction, separation and purification procedure to
  2. customwere reacted

出典と根拠

ORDレコード
ord-902fdf0157684cc2aa9001f5e86a1ebe
出典データセット
uspto-grants-2001_12
特許番号
US06329405B1

反応ノート

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