3-Fluoroaniline → HCID 178500755、化合物

HRID 226965

反応式

HRID 226965 の反応式
[CH3:1][O:2][C:3](=[O:24])[C:4]([C:14](=[O:23])[C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[C:17]([CH3:22])[CH:16]=1)=[CH:5][NH:6][C:7]1[CH:12]=[CH:11][C:10](F)=[CH:9][CH:8]=1.COC(=O)C(C(=O)C1C=CC(C)=C(C)C=1)=COC.[F:43]C1C=C(C=CC=1)N>>[CH3:1][O:2][C:3](=[O:24])[C:4]([C:14](=[O:23])[C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[C:17]([CH3:22])[CH:16]=1)=[CH:5][NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([F:43])[CH:8]=1

参加物

4

反応物 3

HCID 97423-FluoroanilineHCID 668792722-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl esterHCID 178500760HCID 178500760、化合物

生成物 1

HCID 178500755HCID 178500755、化合物収率 50.1%

実験手順

Compound 2h was prepared following the procedure described in Step 1 of Example 1 using from 2g (8.06 mmol) of crude 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester 1a and 0.806 g (7.26 mmol) 3-fluoroaniline. The crude product 2h was purified by recrystalization with dichloromethane/hexane to yield 1.19 g of 2-(3,4-Dimethyl-benzoyl)-3-(3-fluoro-phenylamino)-acrylic acid methyl ester as a brown solid.

後処理

  1. customCompound 2h was prepared
  2. customThe crude product 2h was purified by recrystalization with dichloromethane/hexane

出典と根拠

ORDレコード
ord-19c6e3c0780148ec87451d8ba239704c
出典データセット
uspto-grants-2009_07
特許番号
US07557213B2

関連ノート

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