Potassium Carbonate → 3-[4-(2-Benzofuranyl)thiazol-2-yl]propionic acid

HRID 2269708ノート

反応式

HRID 2269708 の反応式
[OH-].[Na+].[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=[C:4]1[C:12]1[N:13]=[C:14]([CH2:17][CH2:18][C:19]([O:21]CC)=[O:20])[S:15][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=[C:4]1[C:12]1[N:13]=[C:14]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[S:15][CH:16]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 18333015Ethyl 3-[4-(2-benzofuranyl)thiazol-2-yl]propionate

生成物 1

HCID 183330873-[4-(2-Benzofuranyl)thiazol-2-yl]propionic acid収率 73.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1N Sodium hydroxide (3 ml) was added dropwise to a methanol solution (3 ml) of ethyl 3-[4-(2-benzofuranyl)thiazol-2-yl]propionate (460 mg) under ice-cooling. The reaction mixture was stirred at room temperature overnight, to which was added 10% aqueous potassium carbonate solution (10 ml), and the mixture was washed with ethyl acetate. The aqueous layer was made acidic (pH 3) by adding 1N hydrochloric acid and extracted with ethyl acetate. The organic layer was dried and concentrated to obtain the entitled compound (306 mg).

後処理

  1. temperaturecooling
  2. washthe mixture was washed with ethyl acetate
  3. additionby adding 1N hydrochloric acid
  4. extractionextracted with ethyl acetate
  5. customThe organic layer was dried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-6535890dff4a4e68984c103596038338
出典データセット
uspto-grants-2001_12
特許番号
US06329389B1

反応ノート

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