Diphenyl Ether → 3-(3,4-Dimethyl-benzoyl)-6,8-dimethyl-1H-[1,7]naphthyridin-4-one

HRID 226977

反応式

HRID 226977 の反応式
CO[C:3](=[O:18])[C:4]([C:8](=[O:17])[C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([CH3:16])[CH:10]=1)=[CH:5]OC.[CH3:19][C:20]1[C:25]([NH2:26])=[CH:24][CH:23]=[C:22]([CH3:27])[N:21]=1.C1(OC2C=CC=CC=2)C=CC=CC=1>CCCCCC>[CH3:16][C:11]1[CH:10]=[C:9]([CH:14]=[CH:13][C:12]=1[CH3:15])[C:8]([C:4]1[C:3](=[O:18])[C:24]2[C:25](=[C:20]([CH3:19])[N:21]=[C:22]([CH3:27])[CH:23]=2)[NH:26][CH:5]=1)=[O:17]

参加物

5

反応物 3

HCID 7583Diphenyl EtherHCID 769642,6-Dimethyl-3-pyridylamineHCID 668792722-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester

生成物 1

HCID 577547743-(3,4-Dimethyl-benzoyl)-6,8-dimethyl-1H-[1,7]naphthyridin-4-one収率 7.3%

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

反応条件

温度
250 °C

実験手順

0.50 g (2.01 mmol) of 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester and 0.25 g (2.01 mmol) of 2,6-Dimethyl-pyridin-3-ylamine were heated at 100° C. for two hours. After cooling to room temperature 30 mL of diphenyl ether was added and heated at 250° C. for two hours. The reaction was allowed to cool to room temperature and hexane was added. The brown precipitate was collected by filtration to yield 45 mg of 3-(3,4-Dimethyl-benzoyl)-6,8-dimethyl-1H-[1,7]naphthyridin-4-one.

後処理

  1. additionwas added
  2. temperatureto cool to room temperature
  3. filtrationThe brown precipitate was collected by filtration

出典と根拠

ORDレコード
ord-dc698529e612467bb9d0b10d8a737455
出典データセット
uspto-grants-2009_07
特許番号
US07557213B2

関連ノート

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