1-(6-Bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide → 1-(6-Bromo-pyridin-2-ylmethyl)-3-(3-methoxy-benzoyl)-1H-quinolin-4-one

HRID 227048

反応式

HRID 227048 の反応式
CON(C)[C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([Br:24])[N:19]=2)[CH:7]=1)=[O:5].[CH3:26][O:27][C:28]1[CH:29]=[C:30]([Mg]Br)[CH:31]=[CH:32][CH:33]=1>C1COCC1>[Br:24][C:20]1[N:19]=[C:18]([CH2:17][N:8]2[C:9]3[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:15](=[O:16])[C:6]([C:4](=[O:5])[C:32]3[CH:31]=[CH:30][CH:29]=[C:28]([O:27][CH3:26])[CH:33]=3)=[CH:7]2)[CH:23]=[CH:22][CH:21]=1

参加物

4

反応物 2

HCID 577545321-(6-Bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amideHCID 178490745HCID 178490745、化合物

生成物 1

HCID 577545271-(6-Bromo-pyridin-2-ylmethyl)-3-(3-methoxy-benzoyl)-1H-quinolin-4-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Experimental conditions analogous to those described for Step 6 of Example 60 from 90 mg (0.22 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 1.5 mL THF and 0.49 mL 1M 3-methoxyphenylmagnesium bromide. Yield: 53 mg of a white solid. LC-MSD, m/z for C23H17BrN2O3 [M+H]+=449.0, 451.0; HPLC retention time: 2.3 min.

出典と根拠

ORDレコード
ord-9fd93096f60342738d696d5403775015
出典データセット
uspto-grants-2009_07
特許番号
US07557213B2

関連ノート

読み込み中…