Cvt-2738 → 2-{4-[2-hydroxy-3-(2-methyl-benzothiazol-5-yloxy)-propyl]-piperazin-1-yl}-N-(4-hydroxy-phenyl)acetamide
反応式
[CH3:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH:13]3[CH2:15][O:14]3)=[CH:7][C:5]=2[N:6]=1.C([O:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27](=[O:35])[CH2:28][N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[CH:22][CH:21]=1)(=O)C.CC1C=CC=C(C)C=1NC(=O)CN1CCNCC1>>[OH:14][CH:13]([CH2:12][O:11][C:8]1[CH:9]=[CH:10][C:4]2[S:3][C:2]([CH3:1])=[N:6][C:5]=2[CH:7]=1)[CH2:15][N:32]1[CH2:31][CH2:30][N:29]([CH2:28][C:27]([NH:26][C:23]2[CH:24]=[CH:25][C:20]([OH:19])=[CH:21][CH:22]=2)=[O:35])[CH2:34][CH2:33]1参加物
4
実験手順
Compound 54 was prepared in the manner of compound 7 substituting compound 33 for compound 6 and compound 57 for compound 5 in part D of compound 7: Mass Spectrum (MH+)=457.5.