Triethylamine → HCID 18387738、化合物
反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>CC#N>[CH3:20][S:21]([O:12][C:9]1[CH:10]=[CH:11][C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[CH:7][CH:8]=1)(=[O:23])=[O:22]参加物
5
実験手順
To a mixture of 4-(2-thienyl)phenol (1.76 g) and triethylamine (1.50 g) in MeCN (10 ml) was added dropwise methanesulfonylchloride (1.26 g) with ice-cooling. The mixture was stirred for 1 hour, then for 1 hour at ambient temperature. The resulting mixture was concentrated and diluted with a mixture of AcOEt and H2O to separate solid. The separated solid was recovered and washed with H2O and AcOEt to give 1.62 g of 2-(4-methanesulfonyloxyphenyl)thiophene.
後処理
- temperaturecooling
- waitfor 1 hour at ambient temperature
- concentrationThe resulting mixture was concentrated
- additiondiluted with a mixture of AcOEt and H2O
- customto separate solid
- customThe separated solid was recovered
- washwashed with H2O and AcOEt
出典と根拠
- ORDレコード
- ord-2843c759c09148aa83e08f37c873688a
- 出典データセット
- uspto-grants-2001_12
- 特許番号
- US06333324B1
反応ノート
読み込み中…