2-Methyl-1-butanol → N-(phenylacetyl)valine 2-methylbutyl Ester

HRID 2271157

反応式

HRID 2271157 の反応式
[C:1]1([CH2:7][C:8]([NH:10][C@H:11]([C:15]([OH:17])=[O:16])[CH:12]([CH3:14])[CH3:13])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][CH:19]([CH2:22][CH3:23])[CH2:20]O>>[CH3:18][CH:19]([CH2:22][CH3:23])[CH2:20][O:16][C:15](=[O:17])[C@H:11]([CH:12]([CH3:13])[CH3:14])[NH:10][C:8](=[O:9])[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

3

反応物 2

HCID 87232-Methyl-1-butanolHCID 853958(2S)-3-methyl-2-(2-phenylacetamido)butanoic acid

生成物 1

HCID 15481773N-(phenylacetyl)valine 2-methylbutyl Ester

実験手順

Following General Procedure C and using the N-(phenylacetyl)valine prepared in Step A above and 2-methylbutan-1-ol (Aldrich), the title compound was prepared as a diastereomeric mixture. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

後処理

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

出典と根拠

ORDレコード
ord-6d0f34efbb7b445d984ac3f735fc4751
出典データセット
uspto-grants-2001_12
特許番号
US06333351B1

関連ノート

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