Hydrochloric Acid → HCID 178479265、化合物

HRID 2271570ノート

反応式

HRID 2271570 の反応式
[N:1]1([C@H:6]2[CH2:11][CH2:10][C@H:9]([NH:12]C(=O)OC(C)(C)C)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:20].O>C1COCC1>[ClH:20].[N:1]1([C@H:6]2[CH2:11][CH2:10][C@H:9]([NH2:12])[CH2:8][CH2:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 178453978HCID 178453978、化合物

生成物 1

HCID 178479265HCID 178479265、化合物収率 99%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
65 °C

実験手順

To a solution of tert-butyl trans-4-(pyrrolidin-1-yl)cyclohexylcarbamate (399 mg, 1.44 mmol) in THF (12 mL) was added aqueous 6 N HCl (6 mL) and water (6 mL) and the reaction mixture was heated at 65° C. for 18 ht. The reaction mixture was cooled and concentrated to afford the desired product (350 mg, >99%) as an off-white solid: ESI MS m/z 169 [C10H20N2+H]+.

後処理

  1. temperatureThe reaction mixture was cooled
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-8b128e8878524106bc9ff4bbe7d9d355
出典データセット
uspto-grants-2015_09
特許番号
US09120749B2

反応ノート

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