4-Aminobenzonitrile → HCID 3981627、化合物

HRID 2272556ノート

反応式

HRID 2272556 の反応式
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[CH3:10][CH:11]1[CH2:16][C:15](=[O:17])[O:14][C:13](=[O:18])[CH2:12]1>C1COCC1>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([NH:1][C:15](=[O:17])[CH2:16][CH:11]([CH3:10])[CH2:12][C:13]([OH:18])=[O:14])=[CH:3][CH:4]=1)#[N:7]

参加物

4

反応物 2

HCID 133964-AminobenzonitrileHCID 778283-Methylglutaric anhydride

生成物 1

HCID 3981627HCID 3981627、化合物収率 64.8%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 4-aminobenzonitrile (4.61 g, 39.02 mmol) and 4-methyldihydro-2H-pyran-2,6(3H)-dione (5.0 g, 39.02 mmol) in THF (50 mL) was stirred at 90° C. for 14 hr. The reaction solution was concentrated, and the precipitate was washed with ethyl acetate to give 5-(4-cyanophenylamino)-3-methyl-5-oxopentanoic acid (6.23 g, 25.3 mmol, 64.8%).

後処理

  1. concentrationThe reaction solution was concentrated
  2. washthe precipitate was washed with ethyl acetate

出典と根拠

ORDレコード
ord-272c6892a1824a7ab3b18767b4c63451
出典データセット
uspto-grants-2015_09
特許番号
US09120776B2

反応ノート

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