Phenyl Isothiocyanate → 1,3-Dibenzyl-2-oxo-1,4,8-triazaspiro[4,5]decane-8-thiocarboxylic acid phenylamide

HRID 227262ノート

反応式

HRID 227262 の反応式
[C:1]1([N:7]=[C:8]=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:10]([N:17]1[C:21]2([CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)[NH:20][CH:19]([CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:18]1=[O:34])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1(C)C=CC=CC=1>[C:1]1([NH:7][C:8]([N:24]2[CH2:25][CH2:26][C:21]3([N:17]([CH2:10][C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)[C:18](=[O:34])[CH:19]([CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[NH:20]3)[CH2:22][CH2:23]2)=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 7673Phenyl IsothiocyanateHCID 688379421,3-Dibenzyl-1,4,8-triazaspiro[4,5]decan-2-one

生成物 1

HCID 866100631,3-Dibenzyl-2-oxo-1,4,8-triazaspiro[4,5]decane-8-thiocarboxylic acid phenylamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Phenyl isothiocyanate (203 mg, 1.50 mmol) was added to a solution of 1,3-dibenzyl-1,4,8-triazaspiro[4,5]decan-2-one (505 mg, 1.50 mmol) in toluene (14.3 ml) with stirring under a blanket of nitrogen at RT and the reaction mixture was stirred at 50° C. for 8 h. After removal of the solvent, the desired product 1,3-dibenzyl-2-oxo-1,4,8-triazaspiro[4,5]decane-8-thiocarboxylic acid phenylamide was obtained by means of preparative HPLC.

後処理

  1. stirringthe reaction mixture was stirred at 50° C. for 8 h
  2. customAfter removal of the solvent

出典と根拠

ORDレコード
ord-3e1a3287970744f4bbf5080e6a35fb18
出典データセット
uspto-grants-2009_07
特許番号
US07560468B2

反応ノート

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