Sodium Carbonate → 7,8-Dibromo-2-methoxy-[1,5]naphthyridine

HRID 2273210ノート

反応式

HRID 2273210 の反応式
P(Br)(Br)[Br:2].[Br:5][C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1O)=[N:13][C:12]([O:17][CH3:18])=[CH:11][CH:10]=2.C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O>[Br:5][C:6]1[C:15]([Br:2])=[C:14]2[C:9]([CH:10]=[CH:11][C:12]([O:17][CH3:18])=[N:13]2)=[N:8][CH:7]=1

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 24614Phosphorus tribromideHCID 178487833HCID 178487833、化合物

生成物 1

HCID 672578837,8-Dibromo-2-methoxy-[1,5]naphthyridine収率 80.6%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Phosphorus tribromide (140 mg, 0.53 mmol, 1.3 eq) is added at 0° C. to a stirred suspension of 3-bromo-6-methoxy-[1,5]naphthyridin-4-ol (100 mg, 0.39 mmol, 1.0 eq) in N,N-dimethylformamide (1 mL). After 2 hours stirring at room temperature, the reaction mixture is poured into saturated sodium carbonate aqueous solution (50 mL). The resulting suspension is filtered and the cake is washed with water and methanol to afford 7,8-dibromo-2-methoxy-[1,5]naphthyridine as a white solid (100 mg, 80% yield).

後処理

  1. filtrationThe resulting suspension is filtered
  2. washthe cake is washed with water and methanol

出典と根拠

ORDレコード
ord-92f30c14292e46ff82bddab91d9a0b1e
出典データセット
uspto-grants-2015_09
特許番号
US09120822B2

反応ノート

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