(3-Benzyloxy-6-methoxy-[1,5]naphthyridin-4-yl)-methanol → 4-Hydroxymethyl-6-methoxy-[1,5]naphthyridin-3-ol

HRID 2273228ノート

反応式

HRID 2273228 の反応式
C([O:8][C:9]1[CH:10]=[N:11][C:12]2[C:17]([C:18]=1[CH2:19][OH:20])=[N:16][C:15]([O:21][CH3:22])=[CH:14][CH:13]=2)C1C=CC=CC=1>[Pd].CO>[OH:20][CH2:19][C:18]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([O:21][CH3:22])[N:16]=2)[N:11]=[CH:10][C:9]=1[OH:8]

参加物

4

反応物 1

HCID 67255949(3-Benzyloxy-6-methoxy-[1,5]naphthyridin-4-yl)-methanol

生成物 1

HCID 1363983214-Hydroxymethyl-6-methoxy-[1,5]naphthyridin-3-ol収率 81%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

10% Palladium on activated carbon (140 mg, 0.13 mmol, 0.1 eq) is added at room temperature to a stirred solution of (3-benzyloxy-6-methoxy-[1,5]naphthyridine-4-yl)-methanol (390 mg, 1.32 mmol, 1.0 eq) in methanol (30 mL). The resulting mixture is stirred under hydrogen flow (4 bars) at room temperature for 1 hour. The catalyst is then removed by filtration and the solution is concentrated to afford 4-hydroxymethyl-6-methoxy-[1,5]naphthyridin-3-ol as a white solid (220 mg, 81% yield).

後処理

  1. customThe catalyst is then removed by filtration
  2. concentrationthe solution is concentrated

出典と根拠

ORDレコード
ord-43982a0236fe4b679869e0e2c97443ea
出典データセット
uspto-grants-2015_09
特許番号
US09120822B2

反応ノート

読み込み中…