Dichloromethane → HCID 178487954、化合物

HRID 2273237ノート

反応式

HRID 2273237 の反応式
C([O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:19][CH3:20])[N:17]=2)[N:12]=[CH:11][C:10]=1[NH2:21])C1C=CC=CC=1.ClCCl>[Pd].CO>[NH2:21][C:10]1[CH:11]=[N:12][C:13]2[C:18]([C:9]=1[OH:8])=[N:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2

参加物

5

反応物 2

HCID 6344DichloromethaneHCID 672542364-Benzyloxy-6-methoxy-[1,5]naphthyridin-3-ylamine

生成物 1

HCID 178487954HCID 178487954、化合物収率 29%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒2 回

実験手順

10% Palladium on activated carbon (76 mg, 0.07 mmol, 0.1 eq) is added at room temperature to a stirred solution of 4-benzyloxy-6-methoxy-[1,5]naphthyridin-3-ylamine (200 mg, 0.71 mmol, 1.0 eq) in methanol (20 mL). The resulting mixture is stirred under hydrogen flow (3 bars) at room temperature for 16 hours. The catalyst is then removed by filtration and the solution is concentrated to give a residue that is purified by column chromatography (silica gel, eluent: dichloromethane:methanol, 50:1 to 10:1, v/v) to afford 3-amino-6-methoxy-[1,5]naphthyridin-4-ol as a yellow solid (39 mg, 29% yield).

後処理

  1. customThe catalyst is then removed by filtration
  2. concentrationthe solution is concentrated
  3. customto give a residue that
  4. customis purified by column chromatography (silica gel, eluent

出典と根拠

ORDレコード
ord-8afe5a57b7464442a9addcd2f0231ac4
出典データセット
uspto-grants-2015_09
特許番号
US09120822B2

反応ノート

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