Isopropylamine → N-Isopropyl 4-bromo-2-nitroaniline

HRID 2273598ノート

反応式

HRID 2273598 の反応式
[CH:1]([NH2:4])([CH3:3])[CH3:2].[Br:5][C:6]1[CH:11]=[CH:10][C:9](F)=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=1>C(O)C>[Br:5][C:6]1[CH:11]=[CH:10][C:9]([NH:4][CH:1]([CH3:3])[CH3:2])=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=1

参加物

4

反応物 2

HCID 6363IsopropylamineHCID 27363284-Bromo-1-fluoro-2-nitrobenzene

生成物 1

HCID 2759489N-Isopropyl 4-bromo-2-nitroaniline

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Isopropylamine (3 mL) is added to a solution of 4-bromo-1-fluoro-2-nitrobenzene (700 mg, 3.18 mmol) in ethanol. The reaction may be stirred for an appropriate time at an appropriate temperature, such as room temperature for overnight and concentrated. The residue may be purified by any appropriate method such as Biotage column chromatography to give 4-bromo-N-isopropyl-2-nitroaniline (770 mg).

後処理

  1. customThe reaction
  2. concentrationconcentrated
  3. customThe residue may be purified by any appropriate method such as Biotage column chromatography

出典と根拠

ORDレコード
ord-980a8c9d3e1a4af9b12c51bc77ed8f9e
出典データセット
uspto-grants-2015_09
特許番号
US09125901B2

反応ノート

読み込み中…