関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | 1-Methyl-2-piperidinemethanol | HCID 89394 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (1-Methylpiperidin-2-yl)methyl methanesulfonate | HCID 44627021 | — |
反応手順
To a solution of 1-methyl-2-piperidine-methanol (Aldrich, 0.27 mL, 2.1 mmol) in 10 mL tetrahydrofuran (THF) at 0° C. was added triethylamine (0.87 mL, 6.22 mmol) followed by methanesulfonyl chloride (0.24 mL, 3.1 mmol). The mixture was stirred at 0° C. for 10 min then the ice-bath was removed and the reaction mixture was stirred at 23° C. for an additional 1.5 h. The reaction mixture was filtered though Celite with THF and concentrated under reduced pressure. This crude material was used directly in the next reaction.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07560481B2 |
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| 出典データセット | uspto-grants-2009_07 |
|---|
| ORD ID | ord-a17f828435f94eff96c61b543cf3d75e |
|---|
| 出典メモ | uspto-grants-2009_07 |
|---|
