反应详情

温度

0 °C

To a solution of 1-methyl-2-piperidine-methanol (Aldrich, 0.27 mL, 2.1 mmol) in 10 mL tetrahydrofuran (THF) at 0° C. was added triethylamine (0.87 mL, 6.22 mmol) followed by methanesulfonyl chloride (0.24 mL, 3.1 mmol). The mixture was stirred at 0° C. for 10 min then the ice-bath was removed and the reaction mixture was stirred at 23° C. for an additional 1.5 h. The reaction mixture was filtered though Celite with THF and concentrated under reduced pressure. This crude material was used directly in the next reaction.

1. customthe ice-bath was removed
2. stirringthe reaction mixture was stirred at 23° C. for an additional 1.5 h
3. filtrationThe reaction mixture was filtered though Celite with THF
4. concentrationconcentrated under reduced pressure
5. customThis crude material was used directly in the next reaction