Ethyl tetrahydropyran-4-ylacetate → 2-(Oxan-4-yl)ethan-1-ol

HRID 227374

反応式

HRID 227374 の反応式
[H-].[H-].[H-].[H-].[Li+].[Al+3].[O:7]1[CH2:12][CH2:11][CH:10]([CH2:13][C:14](OCC)=[O:15])[CH2:9][CH2:8]1>O1CCCC1>[O:7]1[CH2:12][CH2:11][CH:10]([CH2:13][CH2:14][OH:15])[CH2:9][CH2:8]1

参加物

4

反応物 2

HCID 2773412Ethyl tetrahydropyran-4-ylacetateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 177509442-(Oxan-4-yl)ethan-1-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To 15 mL of tetrahydrofuran (THF) at 0° C. was added LiAlH4 (0.28 g, 7.3 mmol). This mixture was stirred for 10 min then the ethyl tetrahydropyran-4-yl-acetate (Combi-Blocks Inc., 0.50 g, 2.9 mmol) was added. The reaction was stirred for 5 min at 0° C. then was allowed to warm to ambient temperature and was stirred for 90 min. The reaction was quenched with excess NaHSO4.10H2O and was stirred for 60 min. The mixture was filtered through Celite. The filtrate was concentrated to give the title compound which was carried on without further purification. MS (DCI/NH3) m/z 131 (M+H)+.

後処理

  1. stirringThe reaction was stirred for 5 min at 0° C.
  2. stirringwas stirred for 90 min
  3. customThe reaction was quenched with excess NaHSO4.10H2O
  4. stirringwas stirred for 60 min
  5. filtrationThe mixture was filtered through Celite
  6. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-5976d4588e174b91ab708aed313d55d1
出典データセット
uspto-grants-2009_07
特許番号
US07560481B2

関連ノート

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