Thionyl Chloride → (Tetrahydro-2H-pyran-4-yl)acetyl chloride

HRID 227402

反応式

HRID 227402 の反応式
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=O)[CH2:3][CH2:2]1.S(Cl)([Cl:13])=O>>[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([Cl:13])=[O:10])[CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 2773575Tetrahydropyran-4-ylacetic acid

生成物 1

HCID 24229747(Tetrahydro-2H-pyran-4-yl)acetyl chloride

実験手順

A solution of tetrahydropyran-4-yl acetic acid (Combi-Blocks, Inc., 0.18 g, 1.2 mmol) in thionyl chloride (7 mL, 96 mmol, excess) was refluxed for 1 h then was cooled to ambient temperature and concentrated under reduced pressure. The residue was azeotroped twice with 10 mL of benzene to remove any remaining thionyl chloride. The resulting acid chloride was used without further purification.

後処理

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was azeotroped twice with 10 mL of benzene
  3. customto remove any remaining thionyl chloride
  4. customThe resulting acid chloride was used without further purification

出典と根拠

ORDレコード
ord-3bf7479e775c4274a3a075fe423aef04
出典データセット
uspto-grants-2009_07
特許番号
US07560481B2

関連ノート

読み込み中…