4-Bromophenacyl bromide → 2-(4-Bromophenyl)imidazo[1,2-a]pyridine
反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6](=O)[CH2:7]Br)=[CH:4][CH:3]=1.[NH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1.C(=O)([O-])O.[Na+]>C(O)C>[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]2[N:12]=[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]3[CH:7]=2)=[CH:4][CH:3]=1参加物
5
実験手順
15 g (54 mmol) of 4-bromophenacyl bromide and 5.2 g (55 mmol) of 2-aminopyridine were dissolved in 100 mL of ethanol. Then, 7.0 g of sodium hydrogen carbonate was added, and the resultant was heated under reflux for 6 hours. After completion of the reaction, generated crystals were filtered out, washed with water and ethanol, whereby 12.5 g (yield 85%) of 2-(4-bromophenyl)-imidazo[1,2-a]pyridine was obtained.
後処理
- temperaturethe resultant was heated
- temperatureunder reflux for 6 hours
- customAfter completion of the reaction
- filtrationwere filtered out
- washwashed with water and ethanol
出典と根拠
- ORDレコード
- ord-09cf92780b4043478b24e08804267a77
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09126943B2
反応ノート
読み込み中…