N-bromobutanimide → 2-Amino-5-bromo-4-methoxybenzaldehyde

HRID 2274216

反応式

HRID 2274216 の反応式
[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[Br:12]N1C(=O)CCC1=O>ClCCl>[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([Br:12])=[CH:6][C:3]=1[CH:4]=[O:5]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 3235032-Amino-4-methoxybenzaldehyde

生成物 1

HCID 593252582-Amino-5-bromo-4-methoxybenzaldehyde収率 56%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 2-amino-4-methoxybenzaldehyde (6 g, 39.7 mmol) in dichloromethane (100 mL) was added N-bromosuccinimide (7 g, 39.7 mmol). LCMS monitored the reaction until the starting material consumed completely. The reaction mixture was diluted with dichloromethane and water. The separated organic layer was dried sodium sulfate, filtered and concentrated to give the title compound (5 g, 56%) as a yellow solid. MS (ES+) C8H8BrNO2 requires: 229, 231. Found: 230, 232 [M+H]+.

後処理

  1. customthe reaction until the starting material
  2. customconsumed completely
  3. additionThe reaction mixture was diluted with dichloromethane and water
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-13f9a284f91e4c41937f53b20427825b
出典データセット
uspto-grants-2015_09
特許番号
US09126951B2

関連ノート

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