2-Propanone, methylhydrazone → HCID 23635272、化合物

HRID 2274973

反応式

HRID 2274973 の反応式
C(O[CH:4]=[C:5]([C:9](=[O:11])[CH3:10])[C:6](=[O:8])[CH3:7])C.[CH3:12][NH:13][N:14]=[C:15]([CH3:17])[CH3:16]>CCOCC>[CH3:12][N:13]([CH:4]=[C:5]([C:6](=[O:8])[CH3:7])[C:9](=[O:11])[CH3:10])[N:14]=[C:15]([CH3:17])[CH3:16]

参加物

4

反応物 2

HCID 798402-Propanone, methylhydrazoneHCID 2404183-(Ethoxymethylene)pentane-2,4-dione

生成物 1

HCID 23635272HCID 23635272、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
0 °C

実験手順

3-(ethoxymethylene)pentane-2,4-dione (Preparation 2, 8.6 g) was dissolved in Ether (30 mL) and cooled to 0° C. The reaction solution was then slowly treated with 1-methyl-2-(propan-2-ylidene)hydrazine (Preparation 1, 4.8 g) dropwise over 5 minutes, and then warmed and stirred at room temperature overnight. The reaction solution was purified directly by flash column chromatography (Biotage Quad 25; Eluent: 20% EtOH in EtOAc) to afford the title compound as a light red solid. (9.1 g, 84.0%).

後処理

  1. temperaturewarmed
  2. customThe reaction solution was purified directly by flash column chromatography (Biotage Quad 25; Eluent: 20% EtOH in EtOAc)

出典と根拠

ORDレコード
ord-dd42a8b98f1940ffbbe97bea0aee796b
出典データセット
uspto-grants-2015_09
特許番号
US09126999B2

関連ノート

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