Iodoethane → 1-Ethyl-1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde
反応式
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[C:2]1[CH:10]=[O:11].C([O-])([O-])=O.[Cs+].[Cs+].I[CH2:19][CH3:20]>CN(C)C=O>[CH2:19]([N:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[C:2]1[CH:10]=[O:11])[CH3:20]参加物
5
反応条件
- 温度
- 20 °C
実験手順
In a separate reaction: To a suspension of 1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde (600 mg, 4.11 mmol) and Cs2CO3 (2675 mg, 8.21 mmol) in N,N-Dimethylformamide (DMF) (20 mL) stirred under nitrogen at 20° C. was added iodoethane (0.498 mL, 6.16 mmol) dropwise during 0.5 min. The reaction mixture was stirred at r.t. for 1 h, TLC showed complete conversion.
後処理
- customIn a separate reaction
- stirringThe reaction mixture was stirred at r.t. for 1 h
出典と根拠
- ORDレコード
- ord-cd52baf1bd9949548ad3a9399eb9de8b
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09127003B2
反応ノート
読み込み中…