Water → 3-Bromo-6,6-dimethyl-8-(piperidin-4-yloxy)-5,6-dihydro-benzo[b]carbazol-11-one

HRID 2275213ノート

反応式

HRID 2275213 の反応式
[Br:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[C:7](=[O:34])[C:8]4[CH:20]=[CH:19][C:18]([O:21][CH:22]5[CH2:27][CH2:26][N:25](C(=O)C(F)(F)F)[CH2:24][CH2:23]5)=[CH:17][C:9]=4[C:10]([CH3:16])([CH3:15])[C:11]=3[NH:12]2)=[CH:4][CH:3]=1.[OH-].[K+].O>C1COCC1.CO>[Br:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[C:7](=[O:34])[C:8]4[CH:20]=[CH:19][C:18]([O:21][CH:22]5[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]5)=[CH:17][C:9]=4[C:10]([CH3:16])([CH3:15])[C:11]=3[NH:12]2)=[CH:4][CH:3]=1

参加物

6

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 86663823HCID 86663823、化合物

生成物 1

HCID 668349073-Bromo-6,6-dimethyl-8-(piperidin-4-yloxy)-5,6-dihydro-benzo[b]carbazol-11-one

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

3-Bromo-6,6-dimethyl-8-[1-(2,2,2-trifluoro-acetyl)-piperidin-4-yloxy]-5,6-dihydro-benzo[b]carbazol-11-one (Compound T6-1, 28.0 mg, 52.3 μmol) was dissolved in THF (1.00 mL) and methanol (0.50 mL), added with aqueous solution of potassium hydroxide (1.00 mL, 20 wt %), and stirred at room temperature for 1 hr. The reaction solution was added to water, and extracted with mixture solution of chloroform and methanol, and dried over sodium sulfate. Then, after filtering and concentration under reduced pressure, 3-bromo-6,6-dimethyl-8-(piperidin-4-yloxy)-5,6-dihydro-benzo[b]carbazol-11-one was obtained as a crude product.

後処理

  1. extractionextracted with mixture solution of chloroform and methanol
  2. dry with materialdried over sodium sulfate
  3. filtrationThen, after filtering
  4. concentrationconcentration under reduced pressure

出典と根拠

ORDレコード
ord-53ac329044a849088ea473baae6fc755
出典データセット
uspto-grants-2015_09
特許番号
US09126931B2

反応ノート

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