Ammonium Chloride → 2-(2-Bromo-4-methoxyphenyl)propan-2-ol

HRID 2275291

反応式

HRID 2275291 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10](=[O:12])[CH3:11].[CH3:13][Mg+].[Br-].[Cl-].[NH4+]>C1COCC1>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]([OH:12])([CH3:13])[CH3:11]

参加物

5

反応物 3

HCID 25517Ammonium ChlorideHCID 106570061-(2-Bromo-4-methoxyphenyl)ethan-1-oneHCID 178418689HCID 178418689、化合物

生成物 1

HCID 668348332-(2-Bromo-4-methoxyphenyl)propan-2-ol収率 69%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To the mixture of 1-(2-bromo-4-methoxyphenyl)-ethanone (300 mg) dissolved in THF solution (3 ml), MeMgBr (3 M THF solution, 0.52 ml) was added at 0° C. under nitrogen atmosphere. Then, the mixture was stirred at room temperature for 6 hrs. The reaction mixture was added with saturated aqueous solution of ammonium chloride and extracted with ethyl acetate. The organic layer was washed with saturated brine, and the residues obtained after concentration under reduced pressure were purified by silica gel column (ethyl acetate/hexane) to obtain the title compound (220 mg, 69%).

後処理

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. customthe residues obtained
  4. concentrationafter concentration under reduced pressure
  5. customwere purified by silica gel column (ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-93e71be7dfd04c3ba162528591e90903
出典データセット
uspto-grants-2015_09
特許番号
US09126931B2

関連ノート

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