Ethyl Acetate → HCID 178458454、化合物
反応式
C([O:8][C:9](=[O:62])[C@:10]([CH3:61])([CH2:53][O:54][CH:55]1[CH2:60][CH2:59][CH2:58][CH2:57][O:56]1)[CH2:11][C@H:12]([NH:26][C:27]([C:29]1[N:30]=[N:31][N:32](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:33]=1)=[O:28])[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:16][CH:15]=1)C1C=CC=CC=1.CCOC(C)=O>[Pd]>[C:17]1([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:18]=[CH:19][C:14]([CH2:13][C@@H:12]([NH:26][C:27]([C:29]2[N:30]=[N:31][NH:32][CH:33]=2)=[O:28])[CH2:11][C@@:10]([CH3:61])([CH2:53][O:54][CH:55]2[CH2:60][CH2:59][CH2:58][CH2:57][O:56]2)[C:9]([OH:62])=[O:8])=[CH:15][CH:16]=1参加物
4
実験手順
(2S,4R)-5-Biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid benzyl ester (7.5 g, 9.1 mmol) was combined with EtOAc (80 mL, 800 mmol). The resulting clear solution was purged with nitrogen and 10% Pd/C (0.05:0.45, Palladium:carbon black, 1.0 g, 0.94 mmol) was added. The resulting mixture was purged with hydrogen and then hydrogenated overnight at room temperature. The mixture was purged with nitrogen, the solids were filtered off, and the solvent was removed by rotary evaporation to yield the title compound (7 g).