Diisopropylethylamine → HCID 89964581、化合物

HRID 2275503ノート

反応式

HRID 2275503 の反応式
[CH2:1]([C:4]1[CH:8]=[C:7]([C:9]([OH:11])=O)[O:6][N:5]=1)[CH2:2][CH3:3].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[NH2:36][C@H:37]([CH2:46][C:47]1[CH:52]=[CH:51][C:50]([C:53]2[CH:58]=[C:57]([Cl:59])[CH:56]=[CH:55][C:54]=2[F:60])=[CH:49][CH:48]=1)[CH2:38][C@:39]([CH2:44][OH:45])([CH3:43])[C:40]([OH:42])=[O:41].CCN(C(C)C)C(C)C>CN(C=O)C>[Cl:59][C:57]1[CH:56]=[CH:55][C:54]([F:60])=[C:53]([C:50]2[CH:49]=[CH:48][C:47]([CH2:46][C@@H:37]([NH:36][C:9]([C:7]3[O:6][N:5]=[C:4]([CH2:1][CH2:2][CH3:3])[CH:8]=3)=[O:11])[CH2:38][C@:39]([CH2:44][OH:45])([CH3:43])[C:40]([OH:42])=[O:41])=[CH:52][CH:51]=2)[CH:58]=1

参加物

6

反応物 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 200727463-Propyl-1,2-oxazole-5-carboxylic acidHCID 89964351HCID 89964351、化合物

生成物 1

HCID 89964581HCID 89964581、化合物収率 1.8%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

3-Propylisoxazole-5-carboxylic acid (9 mg, 55 μmol) and HATU (20.8 mg, 55 μmol) were combined in DMF (0.2 mL) and allowed to stand at room temperature for 10 minutes. (2S,4R)-4-Amino-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-hydroxymethyl-2-methylpentanoic acid (20 mg, 55 μmol) in DMF and DIPEA (28.6 μL, 164 μmol) were added, and the resulting mixture was stirred for 20 minutes at room temperature. The mixture was concentrated under reduced pressure and the residue was dissolved in AcOH purified by preparative HPLC to yield the title compound (0.5 mg). MS m/z [M+H]+ calc'd for C26H28ClFN2O5, 503.17. found 504.2.

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. dissolutionthe residue was dissolved in AcOH
  3. custompurified by preparative HPLC

出典と根拠

ORDレコード
ord-44d74a44873e451bb6c6d00e251e5074
出典データセット
uspto-grants-2015_09
特許番号
US09126956B2

反応ノート

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