Hydrochloric Acid → Donepezil Hydrochloride

HRID 227557

反応式

HRID 227557 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:21][CH2:20][N:19]([CH2:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH2:18][CH2:17]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[ClH:29]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:17][CH2:18][N:19]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:20][CH2:21]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[ClH:29]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 3152Donepezil

生成物 1

HCID 5741Donepezil Hydrochloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Donepezil free base (10.0 gm) is dissolved in toluene (50 ml) at 25° C., conc. hydrochloric acid (2.8 ml) is added to the solution and stirred for 6 hours at 25° C. to 30° C. The crystals formed are filtered and dried to give 8.2 gm of donepezil hydrochloride form H2.

後処理

  1. customThe crystals formed
  2. filtrationare filtered
  3. customdried

出典と根拠

ORDレコード
ord-59976aee61b74cbba743bbba07a40700
出典データセット
uspto-grants-2009_07
特許番号
US07560560B2

関連ノート

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