Water → HCID 3816170、化合物

HRID 2275784ノート

反応式

HRID 2275784 の反応式
[NH2:1][CH:2]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)[CH2:3][C:4]([OH:6])=[O:5].[C:14]1(=O)[O:19][C:17](=[O:18])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.O>CN(C=O)C>[O:18]=[C:17]1[C:16]2[C:15](=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:14](=[O:19])[N:1]1[CH:2]([C:7]1[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=1)[CH2:3][C:4]([OH:6])=[O:5]

参加物

5

反応物 3

HCID 962WaterHCID 6811Phthalic AnhydrideHCID 5798853-Amino-3-(4-fluorophenyl)propanoic acid

生成物 1

HCID 3816170HCID 3816170、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
135 °C

実験手順

2.0 g of rac-3-amino-3-(4-fluorophenyl)propanoic acid (10.92 mmol) and 1.62 g of phthalic anhydride (10.92 mmol) were dissolved in 9 ml of DMF and heated at reflux at 135° C. overnight. The reaction solution was added to about 200 ml of water. The solid formed was stirred at RT for about 30 min and then filtered off, washed with water and dried under high vacuum. This gave 3.43 g of the title compound (86% of theory, purity about 86%).

後処理

  1. temperatureheated
  2. customThe solid formed
  3. filtrationfiltered off
  4. washwashed with water
  5. customdried under high vacuum

出典と根拠

ORDレコード
ord-be1cb000e0fa40c8a04784395db9e57c
出典データセット
uspto-grants-2015_09
特許番号
US09126998B2

反応ノート

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