Hydrochloric Acid → 1609345-92-7

HRID 2275838ノート

反応式

HRID 2275838 の反応式
FC(F)(F)C(O)=O.[NH2:8][CH2:9][CH:10]([NH:16]C(=O)OCC1C=CC=CC=1)[CH2:11][C:12]([F:15])([F:14])[F:13].[ClH:27].C(OCC)C>CO.[Pd]>[ClH:27].[ClH:27].[F:13][C:12]([F:15])([F:14])[CH2:11][CH:10]([NH2:16])[CH2:9][NH2:8]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 131733425HCID 131733425、化合物

生成物 1

HCID 901144341609345-92-7

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

130 mg of rac-benzyl (1-amino-4,4,4-trifluorobutan-2-yl)carbamate trifluoroacetate (Example 147 A, 0.33 mmol, 1 equivalent) were initially charged in 8.4 ml of methanol, under argon, 35 mg (0.03 mmol) of 10% palladium on activated carbon were added and the mixture was hydrogenated at RT and atmospheric pressure overnight. The mixture was then filtered through a Millipore® filter, 0.33 ml of 2 N hydrochloric acid in diethyl ether (0.66 mmol, 2 equivalents) was added and the mixture was concentrated. This gave 72 mg (100% of theory) of the title compound.

後処理

  1. customwas hydrogenated at RT
  2. customatmospheric pressure overnight
  3. filtrationThe mixture was then filtered through a Millipore®
  4. filtrationfilter
  5. concentrationthe mixture was concentrated

出典と根拠

ORDレコード
ord-0ef5f3d7896f4552801fedeb5aa46d2f
出典データセット
uspto-grants-2015_09
特許番号
US09126998B2

反応ノート

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