HCID 86717937、化合物 → 2-Amino-4-fluoropyridin-3-ol
反応式
[F:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N+:8]([O-])=O)[C:3]=1[OH:11]>C(O)C.[Pd]>[NH2:8][C:4]1[C:3]([OH:11])=[C:2]([F:1])[CH:7]=[CH:6][N:5]=1参加物
4
実験手順
Under argon, 90 mg (0.57 mmol) of 4-fluoro-2-nitropyridin-3-ol Example 266A were dissolved in 30 ml of ethanol, a spatula tip of 10% palladium on activated carbon was added and the mixture was hydrogenated under atmospheric pressure at RT for 1.5 h. The mixture was then filtered off through silica gel and the filter cake was washed with a lot of ethanol. The solution was concentrated and dried. This gave 56 mg (77% of theory) of the title compound.
後処理
- filtrationThe mixture was then filtered off through silica gel
- washthe filter cake was washed with a lot of ethanol
- concentrationThe solution was concentrated
- customdried
出典と根拠
- ORDレコード
- ord-b532794238ae464281b639c71b66e230
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09126998B2
反応ノート
読み込み中…