関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| 反応物 | HCID 178516656 | HCID 178516656 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4,6-Dihydroxy-2-(4-methoxybenzylsulfanyl)pyrimidine | HCID 178491709 | 82.2% |
反応手順
A DMF (500 ml) solution of 4,6-dihydroxy-2-mercaptopyrimidine (50 g, 346 mmol), triethylamine (62.7 ml, 450 mmol), 4-methoxybenzyl chloride (52.8 ml, 381 mmol) was heated and stirred at 100° C. for 1 hour 45 minutes. The reaction solution was poured into water and stirred for a while, and the precipitated crystals were collected by filtration and air-dried to obtain 75.2 g (82% yield) of 4,6-dihydroxy-2-(4-methoxybenzylsulfanyl)pyrimidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09132130B2 |
|---|
| 出典データセット | uspto-grants-2015_09 |
|---|
| ORD ID | ord-e98b9b70765a4320b7a2163bd1a14c57 |
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| 出典メモ | uspto-grants-2015_09 |
|---|
