反应详情

温度

100 °C

A DMF (500 ml) solution of 4,6-dihydroxy-2-mercaptopyrimidine (50 g, 346 mmol), triethylamine (62.7 ml, 450 mmol), 4-methoxybenzyl chloride (52.8 ml, 381 mmol) was heated and stirred at 100° C. for 1 hour 45 minutes. The reaction solution was poured into water and stirred for a while, and the precipitated crystals were collected by filtration and air-dried to obtain 75.2 g (82% yield) of 4,6-dihydroxy-2-(4-methoxybenzylsulfanyl)pyrimidine.

1. stirringstirred for a while
2. filtrationthe precipitated crystals were collected by filtration
3. customair-dried