5-(4-Nitrophenyl)thieno[2,3-d]pyrimidine-2,4-diamine → 5-(4-Aminophenyl)thieno[2,3-d]pyrimidine-2,4-diamine
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:18]3[C:17]([NH2:19])=[N:16][C:15]([NH2:20])=[N:14][C:13]=3[S:12][CH:11]=2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[C:18]3[C:17]([NH2:19])=[N:16][C:15]([NH2:20])=[N:14][C:13]=3[S:12][CH:11]=2)=[CH:8][CH:9]=1参加物
4
実験手順
A suspension of Example 337A (0.26 g) in methanol (5 mL) was stirred under a hydrogen atmosphere (balloon) in the presence of 10% Pd/C (100 mg) for 24 hours, and filtered through diatomaceous earth (Celite®). The pad was washed with methanol and the combined filtrates were concentrated and purified by silica gel chromatography with 7% methanol/dichloromethane to provide 0.127 g of the desired product. MS (ESI(+)) m/e 258 (M+H)+.