1-(2-Methoxyphenyl)piperazine → (3-(2-Fluorophenyl)-5-methylisoxazol-4-yl)(4-(2-methoxyphenyl)piperazine-1-yl)methanone

HRID 2276449ノート

反応式

HRID 2276449 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]([C:13]([OH:15])=O)=[C:11]([CH3:16])[O:10][N:9]=1.Cl.C(N=C=NCCCN(C)C)C.[CH3:29][O:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1>ClCCl>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]([C:13]([N:40]2[CH2:39][CH2:38][N:37]([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=3[O:30][CH3:29])[CH2:42][CH2:41]2)=[O:15])=[C:11]([CH3:16])[O:10][N:9]=1

参加物

5

反応物 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 64841013-(2-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

生成物 1

HCID 66576942(3-(2-Fluorophenyl)-5-methylisoxazol-4-yl)(4-(2-methoxyphenyl)piperazine-1-yl)methanone収率 73.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In a similar manner as described in Example 1, by using dichloromethane (30 mL), 3-(2-fluorophenyl)-5-methylisoxazol-4-carboxylic acid (407 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and 1-(2-methoxyphenyl)piperazine (354 mg, 1.84 mmol), a white solid required compound (532 mg, 1.35 mmol, 73%) was obtained.

出典と根拠

ORDレコード
ord-9b5addecb9be483584ab668ad949d155
出典データセット
uspto-grants-2015_09
特許番号
US09132126B2

反応ノート

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