Dichloromethane → 4,5-Bis(chloromethyl)-2H-1,3-benzodioxole

反応式

O[CH2:2][C:3]1[C:11]2[O:10][CH2:9][O:8][C:7]=2[CH:6]=[CH:5][C:4]=1CO.S(Cl)([Cl:16])=O.[CH2:18]([Cl:20])Cl>>[Cl:16][CH2:2][C:3]1[C:11]2[O:10][CH2:9][O:8][C:7]=2[CH:6]=[CH:5][C:4]=1[CH2:18][Cl:20]

参加物

反応物 3

HCID 6344Dichloromethane

HCID 24386Thionyl Chloride

HCID 596054HCID 596054、化合物

生成物 1

HCID 161004004,5-Bis(chloromethyl)-2H-1,3-benzodioxole

実験手順

A 0° C. solution of (4-hydroxymethyl-1,3-benzodioxol-5-yl)methanol (8.55 g, 47.0 mmoles) from Example 58A in anhydrous methylene chloride (50 mL) was treated dropwise with thionyl chloride (17 mL, 235 mmoles). The mixture was stirred one hour at room temperature and then concentrated under reduced pressure to afford the title compound. MS (DCI) m/z 218 (M+H)+.

後処理

concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード: ord-f2100a8990e8403e911ae02f22ebfeb8
出典データセット: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09133145B2

反応ノート

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