Water → HCID 57755833、化合物

HRID 227695

反応式

HRID 227695 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[C:7]2[NH2:13])([O-:3])=[O:2].[C:14](OC(=O)C)(=[O:16])[CH3:15].[OH2:21].N1[CH:27]=[CH:26]C=CC=1>>[C:14]([N:9]1[C:10]2[C:6](=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:12][CH:11]=2)[C:7]([NH:13][C:26](=[O:21])[CH3:27])=[N:8]1)(=[O:16])[CH3:15]

参加物

5

反応物 4

HCID 962WaterHCID 1049PyridineHCID 7918Acetic AnhydrideHCID 31366553-Amino-5-nitroindazole

生成物 1

HCID 57755833HCID 57755833、化合物収率 91%

実験手順

The product from Step (a) above (3.6 g, 20.2 mmol) was dissolved in pyridine (30 mL), acetic anhydride (4.15 mL, 44 mmol) was added and the mixture was stirred overnight at rt. The red solution was pouted into H2O and the resulting solid was filtered to give the title compunt as a red solid (4.8 g, 91%). NMR 1H NMR (400 MHz, DMSO-D6) δ 11.21 (br s, 1H), 9.08 (s, 1H), 8.46 (s, 2H), 2.51 (s, 3H), 2.23 (s, 3H) (MS m/z 263.2.0 [M+H]+

後処理

  1. filtrationthe resulting solid was filtered

出典と根拠

ORDレコード
ord-1a43f481a3d64d9fbdc7114267fb6e72
出典データセット
uspto-grants-2009_07
特許番号
US07560467B2

関連ノート

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