3-(4-Fluorophenyl)-5-nitro-1H-indazole → 3-(4-fluorophenyl)-1H-indazol-5-amine
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([N+:17]([O-])=O)[CH:15]=3)[NH:10][N:9]=2)=[CH:4][CH:3]=1>CO.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([NH2:17])[CH:15]=3)[NH:10][N:9]=2)=[CH:6][CH:7]=1参加物
4
実験手順
The product from Step (c) (0.5 g, 1.94 mmol) was dissolved in methanol (50 ml) and treated with 5 wt % Palladium on charcoal (0.15 g). The reaction mixture was pressurized with 50 psi of H2 and stirred for 4 hours. The reaction was filtered and concentrated in vacuo to afford the title compound (0.36 g, 81%); MS (ES+) m/e 229 [M+H]+.
後処理
- filtrationThe reaction was filtered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-8bc3732789974c78ae918fca381d4a34
- 出典データセット
- uspto-grants-2009_07
- 特許番号
- US07560467B2
反応ノート
読み込み中…