HCID 57517503、化合物 → 4-(Cyclopropylmethoxy)-3-fluorobenzenamine

HRID 2277153ノート

反応式

HRID 2277153 の反応式
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][C:7]=2[F:15])[CH2:3][CH2:2]1>[C].[Pd].C1COCC1>[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][C:7]=2[F:15])[CH2:2][CH2:3]1

参加物

4

反応物 1

HCID 57517503HCID 57517503、化合物

生成物 1

HCID 196272444-(Cyclopropylmethoxy)-3-fluorobenzenamine収率 99.8%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 1-(cyclopropylmethoxy)-2-fluoro-4-nitrobenzene (3.00 g), 10% palladium-carbon (containing water (50%), 3.00 g) and THF (30 mL) was stirred at room temperature for 1 hr under a hydrogen atmosphere. The catalyst was removed by filtration, and the obtained filtrate was concentrated under reduced pressure to give the title compound (2.57 g).

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-83e46c465d924d5cb0690b86679b2380
出典データセット
uspto-grants-2015_09
特許番号
US09133129B2

反応ノート

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