Diketene → HCID 178468064、化合物

HRID 227722ノート

反応式

HRID 227722 の反応式
[Br:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH2:11])[CH:9]=2)[NH:4][N:3]=1.[CH2:12]=[C:13]1[O:17][C:15](=[O:16])[CH2:14]1>CC#N>[Br:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][C:15](=[O:16])[CH2:14][C:13](=[O:17])[CH3:12])[CH:9]=2)[NH:4][N:3]=1

参加物

4

反応物 2

HCID 12661Diketene2 回HCID 178507356HCID 178507356、化合物

生成物 1

HCID 178468064HCID 178468064、化合物収率 26%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

反応条件

温度
50 °C

実験手順

The product of Step (b) (4.00 g, 18.86 mmol, 1 equiv) was suspended In CH3CN (20 mL). In a separate flask, diketene (1.45 mL, 18.89 mmol, 1 equiv) was dissolved in CH3CN (10 mL) The diketene solution was added to the initial suspension, and the mixture was heated to 50° C. for 18 hours. The reaction mixture was cooled and concentrated en vacuo. The resulting residue was purified by flash chromatography to afford 1.47 g (26%) of the product as a pink solid.

後処理

  1. temperatureThe reaction mixture was cooled
  2. concentrationconcentrated en vacuo
  3. customThe resulting residue was purified by flash chromatography

出典と根拠

ORDレコード
ord-4174d3a74dc64a7c9ee1226d011a163d
出典データセット
uspto-grants-2009_07
特許番号
US07560467B2

反応ノート

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