HCID 178461781、化合物 → HCID 178461779、化合物
反応式
[OH:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][N:5]=[C:4]([O:11][CH2:12][C@@H:13]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH3:14])[CH:3]=1>[Pd].CO>[NH2:8][C:7]1[C:2]([OH:1])=[CH:3][C:4]([O:11][CH2:12][C@@H:13]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:19])[CH3:21])[CH3:14])=[N:5][CH:6]=1参加物
4
実験手順
A mixture of tert-butyl ((2S)-1-((4-hydroxy-5-nitropyridin-2-yl)oxy)propan-2-yl)carbamate (3.84 g) and 10% palladium/carbon (containing water (50%), 0.40 g) and methanol (50 mL) was stirred at room temperature for 15 hr under a hydrogen atmosphere. The catalyst was removed by filtration, and the obtained filtrate was concentrated under reduced pressure to give the title compound (3.35 g).
後処理
- customThe catalyst was removed by filtration
- concentrationthe obtained filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-2f683fcf1ecb4ddbb1dd37aa048a9dba
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09133129B2
反応ノート
読み込み中…