Diisopropylethylamine → HCID 57755825、化合物

HRID 227734ノート

反応式

HRID 227734 の反応式
[CH3:1][C:2]1[NH:7][C:6](=[O:8])[NH:5][CH:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[C:3]=1[C:19]([OH:21])=O.[F:22][C:23]1[CH:24]=[C:25]([NH:30][C:31]2[C:39]3[C:34](=[CH:35][CH:36]=[C:37]([NH2:40])[CH:38]=3)[NH:33][N:32]=2)[CH:26]=[C:27]([F:29])[CH:28]=1.C1CN([P+](Br)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.C(N(C(C)C)CC)(C)C>C(Cl)Cl>[F:22][C:23]1[CH:24]=[C:25]([NH:30][C:31]2[C:39]3[C:34](=[CH:35][CH:36]=[C:37]([NH:40][C:19]([C:3]4[CH:4]([C:9]5[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:18])[F:16])=[CH:11][CH:10]=5)[NH:5][C:6](=[O:8])[NH:7][C:2]=4[CH3:1])=[O:21])[CH:38]=3)[NH:33][N:32]=2)[CH:26]=[C:27]([F:29])[CH:28]=1

参加物

6

反応物 4

HCID 81531DiisopropylethylamineHCID 2733179PyBroPHCID 534821056-Methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acidHCID 69067693HCID 69067693、化合物

生成物 1

HCID 57755825HCID 57755825、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The titled compound was prepared following the procedure of Example 175 using 6-Methyl-2-oxo-4-(4-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid, N3-(3,5-difluoro-phenyl)-1H-indazole-3,5-diamine, PyBroP and diisopropylethylamine in methylene chloride. MS (ESI) m/z=543 [M+H]+.

出典と根拠

ORDレコード
ord-ca989b87fa7942c1b3ce86c2e8db93d2
出典データセット
uspto-grants-2009_07
特許番号
US07560467B2

反応ノート

読み込み中…