Methyl 2-(hydroxymethyl)pyridine-4-carboxylate → Methyl 2-formylisonicotinate
反応式
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[CH:6]=[CH:5][N:4]=1>C(Cl)Cl.O=[Mn]=O>[CH:2]([C:3]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[CH:6]=[CH:5][N:4]=1)=[O:1]参加物
4
実験手順
To a solution of methyl 2-(hydroxymethyl)pyridine-4-carboxylate (30 g, 179.64 mmol) in DCM (1 L) was added MnO2 (93.77 g. 1.0778 mol) at r.t. and stirred overnight. The reaction mixture was then filtered and concentrated to afford the title compound (21.3 g, 72%). [M+H] Calc'd for C8H7NO3, 166. Found, 166.
後処理
- filtrationThe reaction mixture was then filtered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-6c865212858146c2b7ba0698c5b715d8
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09133166B2
反応ノート
読み込み中…