Methanol → 2-(3-Chloro-2-fluorophenyl)ethanamine

HRID 2277578ノート

反応式

HRID 2277578 の反応式
[Cl:1][C:2]1[C:3]([F:11])=[C:4]([CH2:8][C:9]#[N:10])[CH:5]=[CH:6][CH:7]=1.B.CO>C1COCC1>[Cl:1][C:2]1[C:3]([F:11])=[C:4]([CH2:8][CH2:9][NH2:10])[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 887MethanolHCID 6331BoraneHCID 27737242-(3-Chloro-2-fluorophenyl)acetonitrile

生成物 1

HCID 534035832-(3-Chloro-2-fluorophenyl)ethanamine収率 90%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of (3-chloro-2-fluoro-phenyl)-acetonitrile (1.48 g, 8.8 mmol) in anhydrous THF (20 mL) was added a solution of borane (20 mL, 1M in THF) dropwise. The resulting reaction mixture was heated at reflux temperature for 2 hours. After cooling to room temperature, MeOH was added and the mixture was stirred at room temperature for additional 30 min. After removal of volatiles under reduced pressure, desired title product (1.30 g, 90%) was obtained as oil. MS: 174.0 (M+H)+.

後処理

  1. customThe resulting reaction mixture
  2. temperaturewas heated
  3. temperatureat reflux temperature for 2 hours
  4. customAfter removal of volatiles under reduced pressure

出典と根拠

ORDレコード
ord-c55e2cb4209f4c8fbe6ae01e86124df8
出典データセット
uspto-grants-2015_09
特許番号
US09133158B2

反応ノート

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