HCID 86685931、化合物 → HCID 71743949、化合物

HRID 2277603ノート

反応式

HRID 2277603 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6](CC1C=CC(OC)=CC=1)[C:5]2([CH3:22])[CH3:21]>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[NH:6][C:5]2([CH3:22])[CH3:21]

参加物

3

反応物 1

HCID 86685931HCID 86685931、化合物

生成物 1

HCID 71743949HCID 71743949、化合物収率 85.2%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 5-chloro-2-(4-methoxy-benzyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one (0.38 g, 1.2 mmol) in trifluoro acetic acid (5 mL) was heated to reflux for 20 hours. After removal of trifluoro acetic acid under reduced pressure, the crude product was purified by flash column chromatography (silica gel 14 g, 5% to 50% ethyl acetate in DCM) to give the title compound (0.20 g, 85%) as a white solid. MS: 196.1 (M+H+).

後処理

  1. temperatureto reflux for 20 hours
  2. customAfter removal of trifluoro acetic acid under reduced pressure
  3. customthe crude product was purified by flash column chromatography (silica gel 14 g, 5% to 50% ethyl acetate in DCM)

出典と根拠

ORDレコード
ord-2419ad2b92e6414dad2c21b4e5ecc319
出典データセット
uspto-grants-2015_09
特許番号
US09133158B2

反応ノート

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