Trifluoroacetic acid → Piperazine, 1-[[5-(3-fluorophenyl)-2-pyridinyl]methyl]-

HRID 2278271ノート

反応式

HRID 2278271 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][N:15]3[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 89677105HCID 89677105、化合物

生成物 1

HCID 89676965Piperazine, 1-[[5-(3-fluorophenyl)-2-pyridinyl]methyl]-収率 72%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A 100 mL round-bottom flask, was charged with tert-butyl 4-[[5-(3-fluorophenyl)pyridin-2-yl]methyl]piperazine-1-carboxylate (950 mg, 2.56 mmol, 1.00 equiv), dichloromethane (15 mL), trifluoroacetic acid (2 mL). The resulting solution was stirred for overnight at room temperature. The resulting mixture was concentrated under reduced pressure to provide 500 mg (crude) of 1-[[5-(3-fluorophenyl)pyridin-2-yl]methyl]piperazine as yellow oil. LCMS (ESI, m/z): 272 [M+H]+.

後処理

  1. concentrationThe resulting mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-1d95816ae3ec4a22abb7fdca3ecbfdbe
出典データセット
uspto-grants-2015_09
特許番号
US09133148B2

反応ノート

読み込み中…