Hydrochloric Acid → Morpholin-2-ylmethanol hydrochloride
反応式
CO.C([N:10]1[CH2:15][CH2:14][O:13][CH:12]([CH2:16][OH:17])[CH2:11]1)C1C=CC=CC=1.[ClH:18].[H][H]>O1CCOCC1.[OH-].[Pd+2].[OH-]>[ClH:18].[NH:10]1[CH2:15][CH2:14][O:13][CH:12]([CH2:16][OH:17])[CH2:11]1参加物
7
実験手順
In an autoclave under an argon atmosphere at ambient temperature (20° C.), 215 ml of methanol, 1.7 g of palladium hydroxide (12135-22-7), 12.4 g of (4-benzylmorpholin-2-yl)methanol and 15 ml of 4M HCl are successively placed in dioxane. After the autoclave has been closed, the reaction medium is placed under 6 bar of hydrogen at 25° C. for 24 h. The reaction medium is filtered through Clarcel, rinsed several times with methanol; the filtrate is concentrated under reduced pressure. Morpholin-2-ylmethanol hydrochloride (9.65 g) is isolated in the form of a yellow oil.
後処理
- customat ambient temperature
- customAfter the autoclave has been closed
- filtrationThe reaction medium is filtered through Clarcel
- washrinsed several times with methanol
- concentrationthe filtrate is concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-ac0fbc88a6b140e3b7d5029f9c4cb165
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09133168B2
反応ノート
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