Hydrochloric Acid → 4-(Trifluoromethyl)-1H-indole
反応式
CN(C)/[CH:3]=[CH:4]/[C:5]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:6]=1[N+:15]([O-])=O.Cl>C(O)(=O)C.[Fe]>[F:14][C:11]([F:12])([F:13])[C:10]1[CH:9]=[CH:8][CH:7]=[C:6]2[C:5]=1[CH:4]=[CH:3][NH:15]2参加物
5
実験手順
850 mg of powdered iron are added to a solution of 1.2 g of dimethyl[(E)-2-(2-nitro-6-trifluoromethylphenyl)vinyl]amine in 30 ml of acetic acid. The reaction mixture is refluxed for 16 hours and then poured into a solution of hydrochloric acid (HCl, 2N), and extracted with ethyl acetate. The organic phases are washed with a 10% sodium carbonate solution and then with a saturated NaCl solution, dried over magnesium sulfate, filtered, and concentrated under reduced pressure so as to give 959 mg of 4-trifluoromethyl-1H-indole which is used in the next step.
後処理
- temperatureThe reaction mixture is refluxed for 16 hours
- extractionextracted with ethyl acetate
- washThe organic phases are washed with a 10% sodium carbonate solution
- dry with materialwith a saturated NaCl solution, dried over magnesium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure so as
出典と根拠
- ORDレコード
- ord-38d73d714efe44d180f842daa7d47eb9
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09133168B2
反応ノート
読み込み中…