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Methanol → (2-Methylpyrimidin-5-yl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 2-Methylpyrimidine-5-carbaldehyde | HCID 3160970 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 生成物 | (2-Methylpyrimidin-5-yl)methanol | HCID 14686706 | — |
反応手順
A solution of 2-methylpyrimidine-5-carbaldehyde (7.5 g, 0.058 mol) in methanol (370 mL, 9.1 mol) was cooled to 0° C. and treated with sodium tetrahydroborate (3.4 g, 0.090 mol). After 30 min, the reaction was quenched with eq H2O (200 mL) and extracted with ethyl acetate. The organic layer was dried over MgSO4 and concentrated to give the title compound as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09133122B2 |
| 出典データセット | uspto-grants-2015_09 |
| ORD ID | ord-de2a0261964e47fdbe979956c4b1a68e |
| 出典メモ | uspto-grants-2015_09 |