反应详情

A solution of 2-methylpyrimidine-5-carbaldehyde (7.5 g, 0.058 mol) in methanol (370 mL, 9.1 mol) was cooled to 0° C. and treated with sodium tetrahydroborate (3.4 g, 0.090 mol). After 30 min, the reaction was quenched with eq H2O (200 mL) and extracted with ethyl acetate. The organic layer was dried over MgSO4 and concentrated to give the title compound as a yellow solid.

1. customthe reaction was quenched with eq H2O (200 mL)
2. extractionextracted with ethyl acetate
3. dry with materialThe organic layer was dried over MgSO4
4. concentrationconcentrated